A total of 376 people died in Ireland in 2017 due to drug and alcohol overdose, according to the 2017 National Drug-Related Deaths Index.
A third of the drug poisoning deaths involved alcohol, with 61 deaths occurring from alcohol poisoning alone.
There was an increase in stimulant deaths from 48 in 2014 to 65 in 2017, which could be mainly attributed to cocaine and MDMA.
The number of drug-related deaths among people who were injecting at the time of their death fell from 57 in 2014 to 34 in 2017.
There was a marked reduction in poisonings from prescribable drugs, such as benzodiazepines and antidepressants.